Abstract Along with the progress of science and technology, the impact of fake and shoddy commodities on high-qualitative and well-known commodities makes printing and packaging industry pay more and more attention to anti-counterfeit technique,which is also relevant to the daily lives of people. This paper analyzes and discusses the anti-counterfeit technique and relevant chemical knowledge involved in packaging and printing from anti-counterfeit ink, anti-counterfeit paper and anti-counterfeit printing process.