Abstract According to the results of Nobel Prize that Cavendish Laboratory has received during 100 years, the development of physics and other disciplines could open up new fields for the development of chemistry or provide new methods for the solution of chemical problems, such as the discoveries of electron, proton and neutron had made chemical cognition from macrocosm to microcosm, and X-ray crystallography had provided new approaches for the study of crystal structures. In a word, the development of chemistry is not independent, but is rooted in the soil of the development of natural science.