Discussion on the Biosynthesis Mechanism of Aromatic Amino Acids: Taking Phenylalanine as Example
JIANG Zhen-Xiong1,2, WANG Zhipeng A3,4,5*, MA Xin-Yu4, YAN Hui-Juan2, GOU Yun-Zi1, YIN Sheng6, WANG Peng7
1. Department of Biology, Texas A&M University, Texas 77840, USA;
2. Plant Pathology & Microbiology Department, Texas A&M University, Texas 77840, USA;
3. Department of Chemistry, Tsinghua University, Beijing 100084, China;
4. Department of Chemistry, Texas A&M University, College Station, Texas 77840, USA;
5. Division of Genetics, Department of Medicine, Brigham and Women’s Hospital; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA;
6. Nutrition/Metabolism Laboratory, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02138, USA;
7. Department of Burn Surgery, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China
Abstract This paper starts from phosphoenolpyruvic acid and erythrose 4-phosphate for a detailed introduction on the synthesis of chorismate, the common substrate shared by three aromatic amino acids, followed by the analysis on the uniqueness of the phenylalanine biosynthesis as an example from different subject’s perspective. Through comparing and contrasting the discrepancies and similarities of different metabolic pathways from different angles, this manuscript is aimed to work as a compass helping students to establish the methodology on learning interdisciplinary knowledge.
JIANG Zhen-Xiong, WANG Zhipeng A, MA Xin-Yu, YAN Hui-Juan, GOU Yun-Zi, YIN Sheng, WANG Peng. Discussion on the Biosynthesis Mechanism of Aromatic Amino Acids: Taking Phenylalanine as Example[J]. Chinese Journal of Chemical Education, 2021, 42(2): 71-79.
