Design of Comprehensive Organic Experiment: Synthesis and Characterization of N-(Benzyloxy)-2-Chloro-2-Phenylacetamide
WANG Gang1**, SUN Qi1, HE Zhao-Lin1, XI Jiang-Bo1, YUAN Hua1,2, YIN Chuan-Qi1,2
1. School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan 430205, China;
2. National Demonstration Center for Environmental and Chemical Engineering Clean Production Experimental Education, Wuhan Institute of Technology, Wuhan 430205, China
Abstract Using benzaldehyde and malononitrile as starting materials, N-(benzyloxy)-2-chloro-2-phenylacetamide was successfully obtained through a three-steps procedure including Knoevnagel condensation, epoxidation and epoxide ring opening reactions, and the product was characterized by IR and NMR. As a comprehensive organic experiment, the experimental content is quite closely related to the theoretical knowledge points. In combination with the IR and NMR spectroscopy analysis, this experiment improved students' capability of multi-step organic synthesis and spectroscopy analysis. And a good teaching effect could be achieved by the experiment.
WANG Gang**,SUN Qi,HE Zhao-Lin,XI Jiang-Bo,YUAN Hua,YIN Chuan-Qi,. Design of Comprehensive Organic Experiment: Synthesis and Characterization of N-(Benzyloxy)-2-Chloro-2-Phenylacetamide[J]. Chinese Journal of Chemical Education, 2021, 42(8): 49-52.
