Preparation of Indol-Substituted Methane Derivatives in A Solvent-Free and Multi-Component Manner
ZHANG Yan1,2**, ZHU Yi-Pin2, ZHANG Si-Yu2, HE Hui2, CHEN Yu2
1. College of Chemistry and Materials,Zhejiang Normal University,Jinhua 321004,China; 2. College of Teacher Education,Zhejiang Normal University,Jinhua 321004,China
Abstract To complete the undergraduate experience of the organic chemistry majors, we need an effective laboratory course in which students are exposed to modern techniques and analytical thinking in the design of experiments. However, undergraduate students are rarely educated about multicomponent synthesis in the current experimental teaching environment. In 2022, we have offered a new student experiment, “a three-component reaction under operationally-simple solvent-free conditions”, which has been developed and implemented in organic chemistry laboratory course for second-year undergraduate students. In this experiment, commercially available, inexpensive reagents, such as p-methylbenzaldehyde, N-methylindole and 5,5-dimethyl-1,3-cyclohexanedione were used as the reaction substrates, and the rapid sequential action of multiple components in a single reaction flask was creatively achieved to obtain the target product. Notable features of this teaching experiment include multicomponent synthesis and good operability, inexpensive reagents, the absence of catalyst and solvents, and high yield and atomic economy.
ZHANG Yan, ZHU Yi-Pin, ZHANG Si-Yu, HE Hui, CHEN Yu. Preparation of Indol-Substituted Methane Derivatives in A Solvent-Free and Multi-Component Manner[J]. Chinese Journal of Chemical Education, 2023, 44(14): 67-72.
