Experimental Study on “Multidirectional” Synthesis of Salicylaldehyde Oxime
FENG Yu-Ling, TIAN Yu, JI Ling-Min, LUO Mei-Hong, JIA Mi-Ying, SUN Jing-Guo**
National Demonstration Center for Experimental Chemistry Education, College of Chemistry and Materials Science, Hebei Normal University, Shijiazhuang 050024, China
Abstract In view of the problem that existing universities that pay attention to “unit” experiments and multistep “one-directional” organic synthesis experiments, combined with the latest scientific and technological achievements, the multistep “one-directional” synthesis experiment of ketone, oxime, amide in the textbook was improved to synthesize the key intermediate salicylaldehyde oxime using salicylaldehyde as the starting material, and then using this key intermediate salicylaldehyde oxime to synthesize salicylamide, salicylonitrile and benzoisoxazole, respectively. The “multidirectional” synthesis experiment is divided into three modes: synthesis, analysis and characterization. The reaction conditions were optimized through experimental exploration, and the melting point and HPLC analysis of the synthesized products were carried out. The molecular structures of the synthesized products were confirmed by IR, NMR and LC-MS. The content of the experimental design is new, operable, evaluable and generalizable, covering the secondary disciplines of organic chemistry and analytical chemistry, and fitting the development of modern chemistry. According to the actual conditions of experimental platforms in different colleges and universities, the experiment teaching content and mode units can be flexibly reassembled to achieve the training goal of “multidirectional” divergent thinking. The teaching concept and model of “multidirectional” organic synthesis experiment can effectively train college students’ divergent thinking and enhance their innovative ability.
FENG Yu-Ling, TIAN Yu, JI Ling-Min, LUO Mei-Hong, JIA Mi-Ying, SUN Jing-Guo. Experimental Study on “Multidirectional” Synthesis of Salicylaldehyde Oxime[J]. Chinese Journal of Chemical Education, 2023, 44(24): 51-58.
