Application of Computational Optical Rotation Dispersion in the Teaching Process of Determining the Absolute Configurations of Complex Natural Products
LIN Bin**, HAO Jin-Le, CHEN Kai, YU Zhi-Wei
Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China
Abstract The use of quantum chemical methods to calculate the optical rotation dispersion of chiral organic molecules and compare them with experimental data has been widely used in the determination of the absolute configurations of complex natural products. Taking three kinds of natural compounds with an increasing complexity as examples, we showed the applications of quantum chemical calculations in the teaching of optical rotation dispersion. By calculating the optical rotation dispersion and analyzing the molecular structures, it helps students have a more intuitive understanding of optical isomers and their optical properties, which is instructive to students’ understanding of the nature of optical rotation dispersion, and effectively improves students’ interest and enthusiasm. Meanwhile, it allows students to understand the cutting-edge methods of chemical research, broaden students’ horizons, and cultivate students’ ability to solve practical problems.
LIN Bin, HAO Jin-Le, CHEN Kai, YU Zhi-Wei. Application of Computational Optical Rotation Dispersion in the Teaching Process of Determining the Absolute Configurations of Complex Natural Products[J]. Chinese Journal of Chemical Education, 2024, 45(12): 76-81.
