Comprehensive Innovative Experiment Design Based on Integration of Science and Education: Preparation and Properties of Functional Dendritic Peptide Phototherapy System
CHEN Si1**, ZHOU Yu-Tian1, MA Xiao-Yu1, WANG Wen-Song1, LIU Fan1, YAN Guo-Ping1,2, FAN Jin-Xuan3**
1. School of Material Science and Engineering, Wuhan Institute of Technology, Wuhan 430205, China; 2. College of Chemical and Material Engineering, Quzhou University, Quzhou 324000, China; 3. College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
Abstract Based on the charactristics of the course, a comprehensive innovative experiment, preparation and properities of functional dendritic peptide phototherapy system, was desinged. The experiment aimsto solve the defects such as limited water solubility, poor stability, rapid metabolism and indiscriminate toxicity of photosensitizer IR780. The phototherapy system RI was constructed by encapsulating photosensitizer IR780 in the hydrophobic cavity of amphiphilic functional branched peptide by hydrophilic and hydrophobic effect. The performance of phototherapy system RI was characterized by electrospray ionization mass spectrometry, nuclear magnetic resonance spectroscopy, ultraviolet-visible spectrophotometer, particle size and Zeta potentiometer, transmission electron microscopy, photothermal imager and cell experiments, and the experimental skills of students were strengthened in the specific implementation process of the experiment.
CHEN Si, ZHOU Yu-Tian, MA Xiao-Yu, WANG Wen-Song, LIU Fan, YAN Guo-Ping, FAN Jin-Xuan. Comprehensive Innovative Experiment Design Based on Integration of Science and Education: Preparation and Properties of Functional Dendritic Peptide Phototherapy System[J]. Chinese Journal of Chemical Education, 2024, 45(12): 82-89.
