Abstract Chirality is a common phenomenon in nature,and many natural products and active ingredients of pharmaceuticals have chiral structural units.Through asymmetric catalytic strategies,chiral molecules can be synthesized to address relevant needs in pharmaceuticals and other areas.At the current undergraduate teaching level,knowledge about asymmetric catalysis only focus on the basic concepts and judgment methods of chirality,while neglecting how to construct chiral molecules.Therefore,it is an important direction to supplement modern experimental teaching content of organic chemistry by effectively integrating the frontier hot topics of the discipline into undergraduate experimental teaching and expanding the scope of undergraduate experimental teaching.Taking the asymmetric synthesis of α-hydroxy-β-keto acid esters under visible light irradiation as an entry point,this experiment is intended to effectively combine the two frontier topics of organophotochemistry and asymmetric catalysis,and apply them to undergraduate experimental teaching.Through this experiment,on the one hand students can understand the frontier knowledge and enhance their interest in organic chemistry,and on the other hand learn the operations of thin layer chromatography,flash column chromatography and the related instruments.In addition,students will be able to apply the theoretical knowledge to the actual structural analysis,and to exercise their subjective initiative,improve their practical capability and enhance their awareness of environmental protection.
XUAN Jun, LI Qiang-Qiang, ZHOU Hong-Ping, FENG Yan, ZHU Xiao-Jiao. Comprehensive Innovative Experiment:Photochemical Asymmetric Synthesis of α-Hydroxy-β-Keto Acid Esters[J]. Chinese Journal of Chemical Education, 2025, 46(2): 46-52.
