Abstract Chiral drug has been a hot topic of new drug research in the world,The asymmetric oriented synthesis of chiral drug and its intermediate catalyzed by enzyme has many advantages compared with the traditional organic synthesis,such as moderate conditions,no strong acid and alkali as well as high pressure and temperature needed,not strict demand on equipments,faster reaction rate,high stereoselectivity and small environmental pollution,so it belongs to green synthesis technology and has become a most promising preparation method of chiral compound,This paper introduces the way,catalytic mechanism and application of asymmetric oriented synthesis of chiral drugs catalyzed by enzyme,and some of the latest developments.
