Determination of Viscosity-average Relative Molecular Weight of Polyhexamethylene Guanidine Hydrochloride and its Antibacterial Effect
YU Hong-Mei1, JIA Hong-Min1, ZHU Xiu-Hui1,2, CHEN Yang1, PANG Jing1
1. School of Chemical Engineering, University of Science and Technology Liao Ning, Anshan 114051, China;
2. Department of Chemical Engineering, Yingkou Institute of Technology, Yingkou 115014, China
Abstract The average relative molecular weight of polyhexamethylene guanidine hydrochloride, which is a novel polymer disinfectant, is determined by the viscosimetry. Using the literature values of K = 3.8 × 10-3 g/mol and α=1.01, the average relative molecular weight of the self-made polyhexamethylene guanidine hydrochloride is 2495, when its concentration is 0.04 g/mL. The results showed that polyhexamethylene guanidine hydrochloride with different relative molecular weight has certain antibacterial effects on escherichia coli, staphylococcus aureus, staphylococcus and pseudomonas aeruginosa at the same concentrations, and antibacterial effect is increased with the increase of relative molecular weight.
YU Hong-Mei, JIA Hong-Min, ZHU Xiu-Hui, CHEN Yang, PANG Jing. Determination of Viscosity-average Relative Molecular Weight of Polyhexamethylene Guanidine Hydrochloride and its Antibacterial Effect[J]. Chinese Journal of Chemical Education, 2014, 35(18): 22-25.
