Abstract There are many academic problems neglected in the teaching of college chemistry, such as the stage of knowledge and the logicality of the concepts. In this paper, these problems were used to create specific examples to guide students to question, find, analysis and solve the problems, and the new methods of logic, set theory, even fuzzy set theory were used to inspire, train, and improve questioning and innovative spirit of the students effectively. At the same time, the new methods make descriptive chemistry theorized and mathematized proactively.