Abstract Shanghae Serial(1857-1858)is the first comprehensive Chinese magazine in modern Shanghai and has significant effect on the diffusion of modern science. It has been found that "chemistry" appeared in official publication for the first time in Shanghae Serial, and is introduced to Japan. In this paper, a comprehensive chemistry research is presented, including "chemistry", element types, chemical reaction, extraction of metal, composition of substance, conservation of mass in Shanghae Serial. Significance and function of Shanghae Serial in diffusion of chemistry is also introduced.
