Abstract The most generalized disconnection used in retrosynthetic analysis of enones is the aldol condensation. But in some cases, enones can not be disconneted ideally by the aldol reaction. The alternative strategies such as aliphatic Friedel-Crafts acylation, Nazarov reaction, Baylis-Hillman reaction,intramolecular Stetter reaction and Diels-Alder reaction should be attempted according to the structures of target molecules.
