Molecular Mechanism of Chemical Carcinogenesis Related Topics Based on Physical Chemistry Principles of Nucleic Acids
WANG Zhi-Peng1,2
1. Department of Chemistry, Tsinghua University, Beijing 100084, China;
2. Department of Chemistry, Texas A & M University, College Station, TX, 77840, USA
Abstract Nucleic acids (DNA and RNA), as the carriers of genetic information, are one of the most important molecules in the biological systems. As a group of organic molecules, the function has to be closely related and regulated by their structures and chemical properties. This paper starts with analyzing the basic chemical properties of nucleotide and oligonucleotide. Three categories of small molecules are summarized in a detailed and complete manner:molecules reacting with DNA in its resting state causing structural change; molecules reacting with DNA in its activated state causing blocked activity; and molecules causing single nucleotide mutation. The connections have also been discussed between nucleic acid chemistry and chemical carcinogenesis, cancer chemotherapy, as well as chemical mutagenesis. Hope to contribute to the further education and research on the nucleic acid chemistry, biology, and medical science.
WANG Zhi-Peng. Molecular Mechanism of Chemical Carcinogenesis Related Topics Based on Physical Chemistry Principles of Nucleic Acids[J]. Chinese Journal of Chemical Education, 2016, 37(18): 1-9.
