Abstract In regard to the problems often found in the teaching of fine chemicals chemistry for chemical engineering and technology specialty, requirement of society, the relationship between the teachers and the students, the learning status of students and so on were analyzed. Subsequently, Hamburg pedagogy mode was introduced into the teaching of fine chemicals chemistry. A teaching method based on the Hamburg pedagogy mode was established and expanded. The method includes simplification and planning of teaching content, establishment of extracurricular part, application of open and interactive teaching approach and construction of four dimensional integrated learning strategy. By investigation, in terms of effects which included arousing learning interests, understanding, improving initiative and comprehensive ability and the satisfaction which contained the teaching method, content of courses and organization and guidance of teachers, the teaching method based on the Hamburg pedagogy mode was superior to traditional teaching methods. This method not only effectively guided and helped students learning, but also cultivated the students practicing ability and innovative ability.