An Introduction and Discussion of an Undergraduate Experiment Abroad: Quaternary Ammonium Phase Transfer Catalyst and Its Application in Heterogeneous Nucleophilic Substitution Reaction
MA Xin-Yu1, WANG Zhipeng1,2, XU Bing3, WANG Peng4, GOU Yun-Zi5, YAN Hui-Juan3, JIANG Zhen-Xiong5
1. Department of Chemistry, Texas A & M University, College Station, TX 77840, USA;
2. Division of Genetics, Department of Medicine, Brigham and Women's Hospital;Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA;
3. Plant Pathology & Microbiology Department. Texas A & M University, Texas 77840, USA;
4. Department of Burn Surgery, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China;
5. Department of Biology, Texas A & M University, College Station, TX 77840, USA
Abstract This paper introduces "The Application of Phase Transfer Catalyst" as an undergraduate experiment abroad. The design and procedure will be summarized, followed by the analysis of the experimental detail and the discussion of the potential problems. This experiment teaches students about the current organic synthetic strategies and techniques, such as thin-layer chromatography (TLC) and silica column chromatography. The design and achievement of this experiment is worthy to be introduced to the undergraduate experiment in China.
MA Xin-Yu, WANG Zhipeng, XU Bing, WANG Peng, GOU Yun-Zi, YAN Hui-Juan, JIANG Zhen-Xiong. An Introduction and Discussion of an Undergraduate Experiment Abroad: Quaternary Ammonium Phase Transfer Catalyst and Its Application in Heterogeneous Nucleophilic Substitution Reaction[J]. Chinese Journal of Chemical Education, 2019, 40(16): 89-93.
