Design and Practice of Comprehensive Multi-Step Organic Synthesis Experiments Based on Cultivating Students' Scientific Experiment Ability: Synthesis and Characterization of Caffeine
CHENG Hui-Cheng, CHEN Bao-Ru, ZHOU Li-Chao, WANG Min, XU Yi-Hang, ZHOU Jian-Min, HUANG Yan-Xian, MA Jiao-Li**
Development Center of Technology for Fruit & Vegetables Storage and Processing Engineering, College of Chemistry, Guangdong University of Petrochemical Technology, Maoming 525000, China
Abstract Based on the classic experiment ofuniversityorganic chemistry “extracting caffeine from tea leaves”, a comprehensive experiment of “chemical synthesisand characterizationof caffeine” using cyanoacetic acid and dimethyl urea as raw material was designed. The experimental procedure is easy to control, and the repeatability is good. The intermediates and products are characterized by melting point instrument, ultravoilet spectrometer, infrared spectrometer, nuclear magnetic resonance and mass spectrometry. Through the comprehensive design of the experiment, students can not only master the basic experimental operations such as distillation, filtration and recrystallization, but also improve the understanding of the organic compound synthesis research process, and help students to develop comprehensive experimental capabilities.
CHENG Hui-Cheng, CHEN Bao-Ru, ZHOU Li-Chao, WANG Min, XU Yi-Hang, ZHOU Jian-Min, HUANG Yan-Xian, MA Jiao-Li. Design and Practice of Comprehensive Multi-Step Organic Synthesis Experiments Based on Cultivating Students' Scientific Experiment Ability: Synthesis and Characterization of Caffeine[J]. Chinese Journal of Chemical Education, 2020, 41(22): 58-61.
