Innovative Comprehensive Experiment:Synthesis of Benzanilide
SUN Jing-Guo, CAI Le, LIU Jia-Wei, SUN Xiao-Bing, GUO Yong-Yan, WU Zi-Luo, SHI Ying-Ying, FENG Yu-Ling**
National Demonstration Center for Experimental Chemistry Education, College of Chemistry and Materials Science, Hebei Normal University, Shijiazhuang 050024, China
Abstract Oximation reaction and Beckmann rearrangement reaction are important basic experimental contents of organic chemistry specialty in colleges and universities. Current experimental textbooks often use cyclohexanone to prepare caprolactam. However, There is a great loss in the post-treatment of the reaction, resulting in a low yield and it is difficult to monitor the reaction. The experimental results are not ideal. We used benzophenone as reactant to synthesize benzanilide by oximation reaction and Beckmann rearrangement reaction. The product was confirmed by 1H NMR, 13C NMR, IR ect. The experimental results show that the reaction of benzanilide is stable, the reaction phenomenon is clear, the post-treatment is simple, and the yield is high. Monitoring the progress of the reaction through TLC enables students to have a clear understanding and control over the reaction process. The experimental content and time are suitable for the requirements of university experiments. The experiment is comprehensive and has a large expansion space. It can effectively train students' innovative thinking and scientific research consciousness and improve students' experimental skills.
SUN Jing-Guo, CAI Le, LIU Jia-Wei, SUN Xiao-Bing, GUO Yong-Yan, WU Zi-Luo, SHI Ying-Ying, FENG Yu-Ling. Innovative Comprehensive Experiment:Synthesis of Benzanilide[J]. Chinese Journal of Chemical Education, 2020, 41(22): 62-66.
