Abstract While teaching the basic principles and knowledge of thermodynamics in physical chemistry, we can embody Marxist philosophical thoughts, such as the practice is the only criterion to test truth, the absoluteness and relativity of truth, the law of quantitative and qualitative change, the universality and particularity of contradiction, etc. Using Marxist philosophy thoughts, the basic principles of physical chemistry are deeply explained. In the process of studying physical chemistry, the students can not only master the basic principles and knowledge of physical chemistry, but also master the scientific principles and scientific ideas of physical chemistry through Marxist world outlook and methodology.