Research Progress on Synthesis of (+)-Biotin Key Intermediate (3aS,6aR)-Thiolactone
MIAO Li-Ming1, CAI Yan2, XIE Tian3**, MIAO Zhi-Wei1**
1. College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China; 2. Tianjin International Joint Academy of Biomedicine, Tianjin 300457, China; 3. Chifeng Ruiyang Chemical Co., Ltd., Chifeng 024000, China
Abstract (+)-Biotin also known as vitamin H, is an essential vitamin for the maintenance of normal physiological functions in animals. It is an essential substance for the synthesis of vitamin C. (3aS,6aR)-Thiolactone is a key intermediate for (+)-biotin synthesis. Therefore, it is of great significance to study the synthesis methods of (3aS,6aR)-thiolactone. The synthesis methods of (3aS,6aR)-thiolactone include chemical resolution, enantioselective synthesis and chiral source synthesis. This paper reviews the research progress in the synthesis of (3aS,6aR)-thiolactone, which provides a reference for further optimizing the synthesis route of (3aS,6aR)-thiolactone.
MIAO Li-Ming, CAI Yan, XIE Tian, MIAO Zhi-Wei. Research Progress on Synthesis of (+)-Biotin Key Intermediate (3aS,6aR)-Thiolactone[J]. Chinese Journal of Chemical Education, 2023, 44(24): 8-17.
