Innovative Experimental Design of Exploring Organic Chemistry Reaction Mechanism Based on Suzuki-Miyaura Coupling Reaction
CHENG Jing1, JIN Jian1, YANG Xue-Ping1, REN Peng1,2**
1. Experiment and Innovation Education Center, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China; 2. College of Science, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China
Abstract As one of the most effective means to build carbon-carbon bonds, the Suzuki-Miyaura coupling reaction has a wide range of applications in the fields of pharmacy, catalysis, and advanced material preparation. A comprehensive and innovative experiment in organic chemistry was introduced in this article: applying Suzuki-Miyaura coupling reaction to explore the kinetics of organic reaction, clarify the effects of the concentration of various substances on the reaction rate, explain the chemical reaction mechanism more closely. The comprehensive experimental project is helpful to deepen students’ understanding of the mechanism of Suzuki-Miyaura coupling reaction, stimulate students’ interests in scientific research on chemical kinetics, improve students’ practical level in anhydrous-oxygen-free operation and instrumental analysis, also cultivate students’ innovative spirit.
CHENG Jing, JIN Jian, YANG Xue-Ping, REN Peng. Innovative Experimental Design of Exploring Organic Chemistry Reaction Mechanism Based on Suzuki-Miyaura Coupling Reaction[J]. Chinese Journal of Chemical Education, 2023, 44(8): 82-88.
