Abstract Isomers, as a fundamental concept in chemistry, share the same molecular formula but exhibit distinct structural arrangements. The study of isomers has been integral to the development of chemical science. This paper provides a comprehensive review of the discovery and evolution of isomers from the early 19th century onwards. It critically examines their pivotal role in organic and stereochemistry, tracing the significant contributions of chemists such as Whler and Berzelius. Additionally, it elucidates the advancements in fine classification and modern analytical techniques like X-ray diffraction and nuclear magnetic resonance in the 20th century. The broad application potential of isomer research in fields such as materials science and pharmaceutical design is highlighted, offering both historical context and theoretical underpinnings for ongoing chemical investigations.
LIU Yu-Rong, LI Xing-Rong, CHEN Xin-Xin, JIANG Zhi-Yong. Historical Evolution of Isomers Concept and Development of Organic Stereochemistry[J]. Chinese Journal of Chemical Education, 2025, 46(19): 121-127.
