Abstract Using the principles of chemical spatial thinking,a simplified model of the three-dimensional structure of cubane (C8H8) was constructed,resembling the “chair” structure model of benzene (C6H6). A method for rapidly and simply sketching multi-substituted cubane isomers was discovered. The “chair” structure model was employed to analyze the structures of disubstituted and trisubstituted cubane. Furthermore,the structure of tetrasubstituted cubane was analyzed using the “chair plus additional point” model. A novel method for analyzing the enantiomers of multi-substituted cubane was established. This approach may provide new insights for studying the isomers of complex stereo-structures.
YU Wei-Feng. Analysis the Isomers of Multi-Substituted Benzene and Multi-Substituted Cubane[J]. Chinese Journal of Chemical Education, 2025, 46(9): 111-115.
