Green Chemistry Synthesis Toward Key Intermediate of Anti-TB Drug Delamanid:Inquiry-Driven Experimental Pedagogy Design and Implementation
YANG Liu1, HE Wei1**, LI Ming-Hua1, WANG Hai-Bo1, SHI Kang2**, JI Nan1
1. School of Pharmacy, Fourth Military Medical University, Xi’an 710032, China; 2. Office of Academic Affairs, Fourth Military Medical University, Xi’an 710032, China
Abstract To enhance the practical teaching quality in pharmaceutical education,this study integrates frontier research on photocatalysis into science-education synergy by designing an open-ended innovative experiment:The Green Chemical Synthesis of a Critical Intermediate for Delamanid Anti-Tuberculosis Drug.This experiment aligns with the specialized features of organic chemistry in pharmaceutical discipline,providing comprehensive research training that spans the entire process,including photocatalysis-driven pharmaceutical synthesis,reaction condition optimization,product isolation and purification,and structural verification via spectroscopic techniques.By integrating theoretical knowledge with practical application and introducing cutting-edge green synthesis technology,the experiment not only significantly increases students’ motivation and autonomy but markedly strengthens fundamental laboratory skills.Furthermore,it guides students to cultivate green and sustainable synthesis philosophies while fostering critical thinking,inventive spirit,and scientific research literacy.
YANG Liu, HE Wei, LI Ming-Hua, WANG Hai-Bo, SHI Kang, JI Nan. Green Chemistry Synthesis Toward Key Intermediate of Anti-TB Drug Delamanid:Inquiry-Driven Experimental Pedagogy Design and Implementation[J]. Chinese Journal of Chemical Education, 2026, 47(4): 98-105.
