Application of Hofmann Rearrangement Reaction in Organic Synthesis
LI Dejiang1, SUN Bihai2, LI Bin2
1. Department of Chemistry of Yunyang Normal School, Danjiangkou Hubei Province 442700; 2. Department of Pharmaceutical Engineering of Wuhan Institute of Chemical Engineering 430073
Abstract The mechanism of Hofmann rearrangement reaction and the effects of alkyl structure and nucleophilic reagent in medium on the reaction are discussed. Moreover, the application of Hofmann rearrangement reaction in organic synthesis is introduced.