Abstract The Nobel Prize in chemistry 2013 was awarded jointly to three American chemists Martin Karplus, Michel Levitt and Arieh Warshel for the development of multiscale model for complex chemical systems. On the basis of many scientists' work, they combined quantum physics with classical physics and developed the multiscale model in which quantum physics is used in dealing with the heart of molecular structure or chemical reaction, while classical physics is used in the treatments of ambient matters or the environment, and dielectric model is used in the outermost layers. With the help of this model, theoretical calculations of the complex process of chemical reaction, heterogeneous catalysis and spectrum of molecules in solutions can be done by computer programming.