Abstract Silica gel-catalyzed and microwave-irradiated preparation of N-phenylbenzamide under solvent-free condition has been developed as a representative example for the amidation reaction. This experiment utilized chromatography-used silica gel as an environmentally benign catalyst, leading to high catalytic efficiency. Such an amide preparation with benzoic acid and aniline performed by microwave-heating at 120 ℃ in the absence of solvent with a yield greater than 90% within 10 min, was quite atom economical and energy efficient. Therefore, it represented a good example of green chemistry in action.
GONG Xue. Silica Gel-Catalyzed and Microwave-Irradiated Preparation of Aromatic Amide Under Solvent-Free Condition[J]. Chinese Journal of Chemical Education, 2017, 38(10): 53-55.
