Simulative Experiment of Automated Synthesis of 18/19F-Radiopharmaceuticals
YAO Xin-Yue1,2, ZHANG Li-Fang1,2, CAO Jian-Hua1,2, ZHANG Yan1,2, QIAO Jin-Ping1,2, LI Song2,3, ZHU Lin1,2
1. College of Chemistry, Key Laboratory of Radiopharmaceuticals, Ministry of Education, Beijing Normal University, Beijing 100875, China;
2. Engineering Center of Radiopharmaceuticals, Beijing Normal University, Beijing 100875, China;
3. Analytical and Testing Center, Beijing Normal University, Beijing 100875, China
Abstract Radiopharmaceuticals is one of the core technologies of positron emission tomography (PET) for diagnostic imaging of various diseases. To make the 18F (T1/2=110 min) labeled radiopharmaceuticals available for imaging, a rapid, efficient and automated preparation process is required. With the rapid development of PET technology, there is a strong demand for radiopharmaceutical professionals all over the world. In order to cultivate students' interests in radiochemical labeling technology and popularize the knowledge of radiopharmaceuticals, teachers transformed scientific research on labeling 18F processes into an unique teaching practice funded by national 973 and 863 programs. Since 2012, a course entitled "chemical comprehensive design experiment for undergraduate students", a simulative experiment of 18/19F-radiopharmaceutical automated synthesis has been designed and enrolled students majored in chemistry. The teaching experiment was completed by the self-developed auto-synthesizer, Synth8 box, that simulated the synthesis of PET radiopharmaceuticals via electronically controlled valves. The box could be disassembled and assembled by students easily. To avoid handling the radioactive 18F, none radioactive 19F processes were carried out by the Synth8 box. Then, the product was analyzed qualitatively and quantitatively by TLC and LC-MS/MS. This course was closely integrated with the practical application of radiopharmaceuticals and transformed the latest scientific research achievements into teaching practice effectively. This experiment expanded the concept of scientific research for undergraduate students, through which it effectively cultivated and stimulated their scientific research literacy and ability. In the past few years, undergraduate students have actively enrolled and enthusiastically contributed to this course. The students always evaluated the course highly.
YAO Xin-Yue, ZHANG Li-Fang, CAO Jian-Hua, ZHANG Yan, QIAO Jin-Ping, LI Song, ZHU Lin. Simulative Experiment of Automated Synthesis of 18/19F-Radiopharmaceuticals[J]. Chinese Journal of Chemical Education, 2017, 38(2): 24-29.
