Abstract Based on General Senior High School Chemistry Curriculum Standard (2017 Edition) and the chemistry examination syllabus, the promotion of real situation in literacy-based teaching and academic evaluation on the connection of teaching, learning and examination is discussed. Through different types of teaching practice based on real situations, the links between cognitive step construction, theme research task development, textbook content integration, situational unit curriculum construction and social life, production practice, scientific research, experimental inquiry are effectively elaborated. Accordingly, driving tasks for students is set. In the process of solving practical problems, the teaching design strategies of constructing a relational and developmental knowledge framework and cognitive model are made and literacy-based teaching cases are presented.