Abstract Evidence-based reasoning is to infer new knowledge and principles on the basis of mastering evidence. Evidence-based reasoning is of great significance to scientific development, students' learning and development. In teaching, we should cultivate students' thinking mode based on evidence-based reasoning from the following aspects:awakening the evidence-based instinct and developing the consciousness of collecting evidence; learning the skills of scientific reasoning and making reasonable reasoning spontaneously; sharing the results of evidence-based reasoning and experiencing the joy of evidence-based reasoning.