Abstract The 2017 high school chemistry curriculum standard adjusts the curriculum structure. Material structure and nature are one of the modules of the optional compulsory courses. The curriculum standard requires students to master not only the specific knowledge about the microstructure of matters, but also establish the method of research and recognize the microstructure of matters, develop the core competence in discipline such as evidence reasoning and model cognition. Based on the visualization software VESTA and the Protein Data Bank (PDB), this study visualizes the structural model of hemoglobin, cuts out its functional unit “heme” and converts its intracellular fractional coordinates into three-dimensional cartesian coordinates for students to build. In the classroom, the general methods and steps of scientists to solve complex molecular structures are restored as much as possible. Students construct the heme atomic position model during project implementation, use the bond length data to judge the bond relationship between atoms, and use the model to explain the mechanism of hemoglobin oxygenation and poisoning. The core competence in discipline such as evidence reasoning and model cognition has been developed.
WANG Quan, CHEN Ying, SHEN Yu-Xin, WEI Rui, ZOU Zi-Wei, WANG Cong, WANG Lei. Project Teaching Case Based on Complex Molecular Structure Model Construction: Exploration of Heme[J]. Chinese Journal of Chemical Education, 2020, 41(17): 35-42.
