Abstract Project-based learning has a positive role in promoting students’ learning effect and future development. On the basis of practical research, this paper puts forward the principle of chemical project construction, which is to set open tasks around the core concepts of the discipline. The teaching strategy of the project implementation includes three aspects: the student-centered teaching process, the teaching process of team teaching, and the project evaluation focusing on process and reflection. Taking “synthesis and performance test of organic water retaining materials” as a project case, the whole process is described, presenting the project teaching process, and providing reference for practical teaching.