Abstract The preparation of acetylsalicylic acid is a classic organic experiment set up in many universities, but there are some problems in the experiment process, such as unstable results, low yield, and difficult precipitation of crude products due to the formation of oily substances. This study emphasized on improving the hydrolysis methods of acetic anhydride, and optimized the reaction conditions such as reaction temperature, reaction time, product testing and so on. The optimized experimental programs gave the stable and reproducible results, and the yield rate is over 70%. The reaction process of the product and by-product were analysized in theory which help students in-depth understanding the reaction principle. Teaching design contained organic chemistry theoretical knowledge and experimental research findings, which can cultivate effectively scientific thought of combining theory with practice and comprehensive abilities of solving practical problems.
CHENG Shao-Ling, XIE Hong-Xiang, ZHANG Huan. Preparation of Acetylsalicylic Acid:Improvement and Teaching Design on the Classic Experiment[J]. Chinese Journal of Chemical Education, 2023, 44(14): 55-60.
