Abstract The reactions of carbonyl compound are the essential and difficult parts of organic chemistry. Based on the five-dimensional teaching strategy of college organic chemistry, this paper had summarized and proposed an integrative teaching strategy of carbonyl compound under the concept of “three changes”, which were “positivation, transmutation and tautomerization”. Positivation means that if the carbon atom of carbonyl group is more deficient in electron density, it will have a more positive charge and more likely to be attacked by a nucleophile. Transmutation represents the connection of one carbon atom to two highly electronegative atoms or electron withdrawing groups, which can be regarded as potential carbonyl group. Tautomerization refers to the tautomerism of the carbonyl compound and its derivatives. Starting from the concept of “three changes”, specific examples and comprehensive exercises were provided to assist students to learn carbonyl compound more efficiently.
XING Guo-Wen, ZHANG Jing-Dong, LU Zhong-Lin. Integrative Teaching Strategy of Carbonyl Compound Under the Concept of Three Changes: Positivation, Transmutation and Tautomerization[J]. Chinese Journal of Chemical Education, 2023, 44(18): 30-36.
