Abstract Based on the research result of the one-pot total synthesis of natural product Luotonin F, and with the assistance of undergraduate innovative comprehensive experimental platform, the one-pot total synthesis of natural product Luotonin F from simple and readily available substrates was investigated under mild conditions. This experiment transformed the frontier theoretical knowledge of self-directed one-pot synthesis into the total synthesis of Luotonin F. The experiment includes four parts: Literature investigation and analysis, one-pot total synthesis of Luotonin F, spectral data processing and mechanism study. The results show that this teaching practice can significantly improve the students' understanding of the research method of organic synthesis and mechanism study. Moreover, the systematic experimental procedure can help students to master the relevant experimental operating techniques, and the testing principles and operating skills of large-scale instruments such as nuclear magnetic resonance. students' comprehensive quality in literature retrieval, synthesis route design, synthesis operation, and spectra analysis will be trained in this experiment. Their interests in scientific research and innovative consciousness of solving problems independently can be further enhanced.
WU Yan-Dong, FEI Zheng, QIU Ming-Qiang, HUANG Chun, WU An-Xin. Teaching of Innovative and Comprehensive Experiment Based on One-Pot Total Synthesis of Luotonin F[J]. Chinese Journal of Chemical Education, 2023, 44(2): 55-61.
