Abstract Nanotechnology leads the research progress in chip, energy, catalysis, and other fields. The authors have carried out beneficial exploration and practice on how to dig out the elements of beauty from this course, to achieve the effect of knowledge education and aesthetic education of science and technology. By combing the course content, a new teaching pattern of “knowledge imparting-aesthetic appreciation-artistic creation” is formed, and the aesthetic connection of “beauty of nanostructure”, “logic beauty of nano-research”, and “beauty of creation on micro-and nano-world” is condensed. All above can realize the integration of science and technology and art, and achieve the purpose of both harvesting knowledge and educating people aesthetically.