Abstract Yu He-Qin, born out of traditional scholar at the end of the Qing Dynasty and the Republic of China, was a new-typed scholar committed to the practice of sinification of science. This paper introduced Yu He-Qin's effort to establish Kaicheng Acid Plant, to financing Kaicheng Acid Company, to trial-produce and produce sulfuric acid production, and so on; and pointed out that as an initiator of national sulphuric acid enterprises which had balanced foreign enterprises, he should be recorded in the history of modern Chinese chemical industry.