Research-Based Comprehensive Chemistry Experiment: Investigation of the Host-Guest Interactions Between Benzo-21-Crown-7 and Secondary Dialkylammonium Salts
HE Tian, FAN Yi-Qi, YIN Shou-Chun**
Provincial Chemical Experimental Teaching Demonstrating Center, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, China
Abstract The discovery of crown ethers opened up a new discipline-supramolecular chemistry. The synthesis and characterization of this kind of substances were introduced into a comprehensive chemistry experiment in our college. A typical crown ether compound, named benzo-21-crown-7 (B21C7), was first synthesized by etherification reaction, and a complex (referred to as pseudorotaxane) was then formed by the host-guest interactions of B21C7 with secondary dialkylammonium salts. Moreover, its complexation ability between B21C7 and secondary dialkylammonium salts was investigated via nuclear magnetic resonance titration. The implementation of this experiment can not only improve the basic experimental operation ability of students, consolidate the understanding of professional knowledge, and train the ability of large-scale instrument test and analysis of students, but also widen the scientific research vision of students and improve their awareness of exploration and innovation. Thus, this experiment was suggested to set up to senior undergraduates and junior postgraduate.
HE Tian, FAN Yi-Qi, YIN Shou-Chun. Research-Based Comprehensive Chemistry Experiment: Investigation of the Host-Guest Interactions Between Benzo-21-Crown-7 and Secondary Dialkylammonium Salts[J]. Chinese Journal of Chemical Education, 2021, 42(4): 62-68.
