The Other Side of Coin:Non-Classical Grignard Reaction
SHEN Ru-Wei1,2**, FAN Yi-Shuai1
1. College of Chemical Engineering,Nanjing Tech University,Nanjing 211816,China; 2. State Key Laboratory of Materials-Oriented Chemical Engineering,Nanjing Tech University,Nanjing 211816,China
Abstract Grignard reaction,one of the most important carbon-carbon bond formation reactions in organic synthesis,represents an important tool for the synthesis of alcoholic compounds.When the rate of a Grignard reaction is greatly reduced due to the stereo-or electronic effect of the carbonyl group or(and)the Grignard reagent,other reaction processes such as enolization,reduction,substitution reaction,etc.may proceed dominantly.However,there is scarcely a systematic introduction on these unusual Grignard reactions.Based on the teaching and research experience of the authors in synthetic organic chemistry,this paper presents a comprehensive introduction on some non-classical Grignard reactions with emphasis on explaining and elucidating the mechanisms of these reactions.
