Green Chemistry Laboratory Experiment:Photo-Induced Catalytic Oxidation of Indanol to Indanone
TAN Fang-Fang1**, TIAN Qing-Chun1, WANG Cheng1, ZHOU Xiao-Qiang1, LI Yang2**
1. School of Chemistry and Materials Science,Weinan Normal University,Weinan 714099,China; 2. Frontier Institute of Science and Technology,Xi’an Jiaotong University,Xi’an 712046,China
Abstract Integrating green chemistry principles into undergraduate laboratory education,this study develops an innovative teaching experiment through visible-light photocatalytic oxidation of 1-indanol to 1-indanone using ambient air as the oxidant,an acridinium salt photosensitizer,and acetonitrile solvent under 420～430 nm blue light irradiation for 1 hour(80% isolated yield).This protocol demonstrates superior sustainability over traditional metal-catalyzed or stoichiometric oxidant systems via mild conditions,operational safety,and high atom economy.The integrated“synthesis-monitoring-separation-characterization”pedagogy incorporates thin-layer chromatography for real-time reaction tracking,column chromatography for purification,NMR spectroscopy for structural confirmation,and exploratory modules for photosensitizer/solvent optimization.This design enables students to master organic photocatalysis,separation techniques,and spectral interpretation while enhancing scientific reasoning and green chemistry literacy,establishing a transferable mode for pharmaceutical intermediate synthesis education.
TAN Fang-Fang, TIAN Qing-Chun, WANG Cheng, ZHOU Xiao-Qiang, LI Yang. Green Chemistry Laboratory Experiment:Photo-Induced Catalytic Oxidation of Indanol to Indanone[J]. Chinese Journal of Chemical Education, 2026, 47(6): 62-68.
