Molecular Structural Characteristics, Synthesis Process, Medicinal Value, and Application Fields of Cooling Agents
XIAO Xiao1**, LING Yun-Hua1, DING Zhuo-Yuan1, LIU Cheng-Jie1, HU Wei1, WANG Long-Long2, CAO Zhong-Yan3, SUN Bin1**, JIANG Xue-Feng4**
1. Institute of Pharmaceutical Science and Technology,Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals,Zhejiang University of Technology,Hangzhou 310014,China; 2. Xiajiang Middle School, Ji'an 331409,China; 3. College of Chemistry and Molecular Sciences,Henan University,Kaifeng 475004, China; 4. School of Chemistry and Molecular Engineering,Shanghai Key Laboratory of Green Chemistry and Chemical Progress,East China Normal University,Shanghai 200062,China
Abstract Cooling sensation is an indispensable sensory experience in daily diet.Its physiological mechanism arises from the stimulation of oral sensory neurons by cooling agents,followed by the formation of a cooling perception in the central nervous system.From a chemical perspective,this paper systematically reviews common cooling agents used in daily life,summarizes their molecular structural features,synthetic processes,medicinal chemistry properties,and application fields.It is intended to enhance readers' understanding of the chemistry underlying cooling sensation and provide a scientific basis for the further development and application of these compounds.
XIAO Xiao, LING Yun-Hua, DING Zhuo-Yuan, LIU Cheng-Jie, HU Wei, WANG Long-Long, CAO Zhong-Yan, SUN Bin, JIANG Xue-Feng. Molecular Structural Characteristics, Synthesis Process, Medicinal Value, and Application Fields of Cooling Agents[J]. Chinese Journal of Chemical Education, 2026, 47(16): 1-11.
