化学·生活·社会
肿瘤PET示踪剂核素标记中的基础化学
杨雪梅1 , 乔雨宸2 , 郝亚萌1 , 王志鹏3,4* , 任鹏1*
1.哈尔滨工业大学(深圳)理学院 广东深圳 518055;
Basic Chemistry in Radionuclide Labeling of Tumor PET Tracers
YANG Xue-Mei1 , QIAO Yu-Chen2 , HAO Ya-Meng1 , WANG Zhipeng A3,4* , REN Peng1*
1. School of Science,Harbin Institute of Technology(Shenzhen),Shenzhen 518055,China;
摘要： 癌症作为全球主要的致死原因之一,对公共卫生构成了巨大的挑战。癌症的防控策略不仅需要治疗技术的进步,也同样需要诊断技术的发展。肿瘤的发生和发展伴随着细胞结构和功能的多种变化,以及肿瘤微环境的显著改变。在这些变化过程中,特定分子的表达水平会出现异常,这些异常表达的分子可以作为肿瘤诊断的生物标志物。近年来,正电子发射断层扫描(Positron Emission Tomography,简称PET)作为一种重要的分子成像技术,已被广泛应用于检测肿瘤的结构和功能变化。PET技术的核心在于放射性示踪剂的开发与应用,这些示踪剂的设计和合成一般基于化学原理的深入理解和创新应用。本文旨在综述PET中几种典型的放射性示踪剂,并探讨核素标记过程中涉及的化学原理,增进对PET在肿瘤诊断中应用的理解,并提升对化学在生物医学领域中作用的认识。此外,PET放射性示踪剂的设计和合成过程是化学教育的宝贵资源,对化学在生命科学相关学科的教学具有重要意义。
关键词： 癌症 ,
肿瘤诊断 ,
正电子发射断层 ,
放射性示踪剂 ,
化学应用
收稿日期: 2024-06-19
通讯作者:
*王志鹏,E-mail:wzpchem1991@gmail.com;任鹏,E-mail:repeng@hit.edu.cu
引用本文:
杨雪梅, 乔雨宸, 郝亚萌, 王志鹏, 任鹏. 肿瘤PET示踪剂核素标记中的基础化学[J]. 化学教育（中英文）, 2025, 46(6): 1-10
[1]
王志鹏,申镇,蒋振雄,等.化学教育(中英文),2021,42(16):1-10
[2]
王志鹏,程农壹,马新雨,等.化学教育(中英文),2019,40(10):12-18
[3]
张淑贤,乔晋萍,李崧,等.化学教育,2015,36(14):1-5
[4]
姚新月,张利芳,曹建花,等.化学教育(中英文),2017,38(2):24-29
[5]
Bray F,Laversanne M,Weiderpass E,et al.Cancer,2021,127(16):3029-3030
[6]
Ferlay J,Colombet M,Soerjomataram I,et al.International Journal of Cancer,2021,149(4):778-789
[7]
Marusyk A,Polyak K.Biochimica et Biophysica Acta,2010,1805(1):105-117
[8]
Hanahan D,Weinberg R A.Cell,2011,144(5):646-674
[9]
Swain S M,Shastry M,Hamilton E.Nature Reviews:Drug Discovery,2023,22(2):101-126
[10]
Paquette M,Lavallée É,Phoenix S,et al.Journal of Nuclear Medicine,2018,59(2):197-203
[11]
Ristau B T,O′keefe D S,Bacich D J.Urologic Oncology,2014,32(3):272-279
[12]
Junttila M R,De Sauvage F J.Nature,2013,501(7467):346-354
[13]
Fan P,Zhang N,Candi E,et al.Oncogene,2023,42(49):3591-3604
[14]
Guelfi S,Hodivala-Dilke K,Bergers G.Nature Reviews Cancer,2024,24(10):655-675
[15]
Voron T,Colussi O,Marcheteau E,et al.Journal of Experimental Medicine,2015,212(2):139-148
[16]
Robert C.Nature Communications,2020,11(1):3801
[17]
Sharma P,Goswami S,Raychaudhuri D,et al.Cell,2023,186(8):1652-1669
[18]
Dall’olio F G,Marabelle A,Caramella C,et al.Nature Reviews Clinical Oncology,2022,19(2):75-90
[19]
Lewis D Y,Soloviev D,Brindle K M.Cancer Journal,2015,21(2):129-136
[20]
Schwenck J,Sonanini D,Cotton J M,et al.Nature Reviews Cancer,2023,23(7):474-490
[21]
Phelps M E.Proceedings of the National Academy of Sciences of the United States of America,2000,97(16):9226-9233
[22]
Beyer T,Townsend D W,Brun T,et al.Journal of Nuclear Medicine,2000,41(8):1369-1379
[23]
Al-Nabhani K Z,Syed R,Michopoulou S,et al.Journal of Nuclear Medicine,2014,55(1):88-94
[24]
Schöder H,Erdi Y E,Larson S M,et al.European Journal of Nuclear Medicine and Molecular Imaging,2003,30(10):1419-1437
[25]
Vāvere A L,Scott P J H.Seminars in Nuclear Medicine,2017,47(5):429-453
[26]
Pichler V,Berroterán-Infante N,Philippe C,et al.Journal of Nuclear Medicine,2018,59(9):1350-1354
[27]
Brasse D,Nonat A.Dalton Transactions,2015,44(11):4845-4858
[28]
Rösch F.Recent Results in Cancer Research,2013,194:3-16
[29]
Abrantes A M,Pires A S,Monteiro L,et al.Biochim Biophys Acta Mol Basis Dis,2020,1866(6):165717
[30]
Nayak T K,Brechbiel M W.Bioconjugate Chemistry,2009,20(5):825-841
[31]
De Feo M S,Pontico M,Frantellizzi V,et al.Clinical and Translational Imaging,2022,10(1):23-36
[32]
Rong J,Haider A,Jeppesen T E,et al.Nature Communications,2023,14(1):3257
[33]
Goud N S,Joshi R K,Bharath R D,et al.European Journal of Medical Chemistry,2020,187:111979
[34]
Preshlock S,Tredwell M,Gouverneur V.Chemical Reviews,2016,116(2):719-766
[35]
Velikyan I.Theranostics,2013,4(1):47-80
[36]
Buck A K,Reske S N.Journal of Nuclear Medicine,2004,45(3):461-463
[37]
Fletcher J W,Djulbegovic B,Soares H P,et al.Journal of Nuclear Medicine,2008,49(3):480-508
[38]
Yu S.Biomedical Imaging and Intervention Journal,2006,2(4):e57
[39]
Peck M,Pollack H A,Friesen A,et al.Quarterly Journal of Nuclear Medicine and Molecular Imaging,2015,59(1):95-104
[40]
Bodapati S,Abraham P,Chen A,et al.Tomography,2022,8(2):1060-1065
[41]
Michaud L,Touijer K A,Mauguen A,et al.Journal of Nuclear Medicine,2020,61(6):827-833
[42]
Szydło M,Jadwiński M,Chmura A,et al.Contemp Oncol(Pozn),2016,20(3):229-236
[43]
Comar D,Cartron J,Maziere M,et al.European Journal of Nuclear Medicine,1976,1(1):11-14
[44]
Soloviev D,Tamburella C.Applied Radiation and Isotopes,2006,64(9):995-1000
[45]
杨雪梅,王志鹏,张永臻,等.化学教育(中英文),2024,45(6):99-107
[46]
Ajish Kumar K S,Mathur A.European Journal of Medicinal Chemistry Reports,2021,3:100014
[47]
Chatterjee S,Lesniak W G,Miller M S,et al.Biochemical and Biophysical Research Communications,2017,483(1):258-263
[48]
Meyer J P,Adumeau P,Lewis J S,et al.Bioconjugate Chemistry,2016,27(12):2791-2807
[49]
Dammes N,Peer D.Theranostics,2020,10(2):938-955
[50]
De Silva R A,Kumar D,Lisok A,et al.Molecular Pharmaceutics,2018,15(9):3946-3952
[51]
Chomet M,Schreurs M,Bolijn M J,et al.European Journal of Nuclear Medicine and Molecular Imaging,2021,48(3):694-707
[52]
Lesniak W G,Chatterjee S,Gabrielson M,et al.Bioconjugate Chemistry,2016,27(9):2103-2110
[53]
Mossine A V,Tanzey S S,Brooks A F,et al.Nature Protocols,2020,15(5):1742-1759
[54]
Doi H.J. Labelled Comp. Radiopharm.,2015,58(3):73-85
[55]
Lanzenberger R R,Mitterhauser M,Spindelegger C,et al.Biological Psychiatry,2007,61(9):1081-1089
[56]
Dahl K,Schou M,Amini N,et al.European Journal of Organic Chemistry,2013,2013(7):1228-1231
