1.Division of Genetics, Department of Medicine, Brigham and Women’s Hospital; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; 2.Department of Chemistry, Texas A&M University, College Station, TX 77840, USA; 3.清华大学化学系 北京 100084; 4.Department of Biology, Texas A&M University, College Station, TX 77840, USA; 5.Computational Biology and Bioinformatics Program, Duke Center for Genomics and Computational Biology, Duke University School of Medicine, Durham, NC 27705, USA; 6.Department of Microbiology, Miami University, Oxford, OH 45056, USA; 7.Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA; 8.清华大学生命学院 北京 100084; 9.Department of Mathematics, Harvard University, MA 02138, USA; 10.Citadel Securities, LLC, 131 South Dearborn St. Chicago Illinois 60603, USA