Coordination Chemistry Characteristics of NOTA Groups and Its Applications and Challenges in Radionuclide Labeling and Intelligent Drug Delivery Systems
LYU Shu-Peng, MAO Tie-Zhu*
The Second Hospital of Jilin University, Jilin University, Changchun 130024, China
Abstract As a hexadentate macrocyclic ligand,NOTA(1,4,7-triazacyclononane-N,N′,N″-triacetic acid) has demonstrated revolutionary potential in coordination chemistry and biomedicine due to its unique N3O3 coordination mode and rigid structure.This review systematically elucidates the coordination chemistry of NOTA,revealing its high thermodynamic stability achieved through synergistic nitrogen-oxygen coordination,along with its size selectivity and stepwise kinetic regulation mechanisms.In practical applications,NOTA and its functionalized derivatives have become pivotal tools for radionuclide labeling,driving advancements in targeted PET imaging probes,multimodal imaging systems,and theranostic platforms.Innovative studies highlight that NOTA derivatives significantly enhance probe hydrophilicity and tumor-targeting efficiency via click chemistry and PEGylation strategies.Furthermore,NOTA-based chelation has achieved breakthroughs in antibacterial applications and smart drug delivery systems.This review also addresses challenges in clinical translation,including kinetic limitations of chelation and metabolic stability issues,while envisioning future prospects for intelligent NOTA systems in precision medicine.
LYU Shu-Peng, MAO Tie-Zhu. Coordination Chemistry Characteristics of NOTA Groups and Its Applications and Challenges in Radionuclide Labeling and Intelligent Drug Delivery Systems[J]. Chinese Journal of Chemical Education, 2026, 47(8): 1-9.
