Abstract A comprehensive teaching experiment has been developed for senior undergraduates,centered on the decarbonylative deuteration of aromatic aldehydes.By integrating concepts of photochemistry and isotope chemistry,the experiment highlights a dual-catalytic strategy employing a photosensitizer and a cobalt complex,proceeding under light irradiation at room temperature with heavy water as the deuterium source.This reaction is characterized by its green,efficient,and site-selective nature.To enhance pedagogical value,project-based teaching was adopted with tasks structured around four guiding questions that direct students through control experiments,spectral interpretation,and mechanistic reasoning.The course design encompasses pre-lab preparation,hands-on experimentation,structural characterization,and innovative extension activities,aiming to foster scientific thinking and strengthen problem-solving skills.By bridging textbook knowledge and authentic research practice,this work embodies the principle of“integration of science and education with competence orientation”and offers a transferable model for comprehensive organic chemistry laboratory instruction.
XU Wen-Han, ZHENG Dong-Cheng, ZHANG Zhi-Han, ZUO Ling-Zi, FANG Zheng-Ping, YU Zhi-Cheng, YE Fei. Integrated Experimental Design of Deuteration Reactions Based on Project-Based Learning[J]. Chinese Journal of Chemical Education, 2026, 47(16): 38-46.
