Abstract A large body of research shown difficulties for students to establish macroscopic,microscopic,and symbolic representation and effective connections among them,which leads to students'a large number of misconceptions and learning disabilities in chemistry.To solve this problem,numerous scholars in west countries widely used computer models in chemistry teach-ing and achieved significant improvement.However,research in such field in China is pretty lag-ging behind.Based on empirical research,this paper summarized serial computer model-based teaching strategies in high school chemistry,and further discussed them with exampling related concrete teaching cases.These strategies include:using computer models to (a) create problem situations to inspire students thinking;(b)present the macro and micro phenomenon to help students understand scientific knowledge;(c)engage students in scientific methods and improve their inquiry ability;(d)guide students'questioning and reflection to deepen their understanding on the nature of science models;(e)construct model and enhance students'modeling skills.In the last part,we proposed some suggestions on computer model-based teaching in chemistry.