Abstract The Nobel Prize in Chemistry 2004 was awarded to three scientists:Aaron Ciechanover,Avram Hershko and Irwin Rose.They succeeded in showing how proteins are destroyed in cells.The article introduce their discovery,especially the substances wanted in the course of the ubiquitin-mediated protein degradation and the mechanism.
LI Yanwu, TAN Weibing, KUANG Xueying, ZHANG Wei. Ubiquitin-mediated Protein Degradation The Introduction of the Nobel Prize in Chemistry 2004[J]. , 2004, 25(11): 6-7,32.
