冷冻电子显微镜:打开生物分子结构大门的钥匙——2017年诺贝尔化学奖解读

doi:10.13884/j.1003-3807hxjy.2017120039

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摘要：理查德·亨德森（Richard Henderson）利用电子显微镜技术首次获得了原子级分辨率的蛋白质3D结构图，开启了揭秘生物分子结构测定的新时代；约阿希姆·弗兰克（Joachim Frank）研发了一种新的由2D结构图合成3D结构图的分析方法，打破了生物样本排列规则、朝向固定、结构均一的限制；雅克·杜波谢（Jacques Dubochet）成功研发了可以迅速将液态水冷却成玻璃态水的技术，较好地解决了冰晶体分散电子束和破坏生物分子结构的问题。3位科学家因"为测定溶液中生物分子的高分辨率结构而研发了冷冻电子显微镜（cryo-electron microscopy，简称为Cryo-EM）技术"，荣获了2017年诺贝尔化学奖。

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关键词： 诺贝尔化学奖, 冷冻电子显微镜, 生物分子结构测定

通讯作者: 王磊 E-mail: wangleibnu@126.com

引用本文:

李川, 王磊. 冷冻电子显微镜:打开生物分子结构大门的钥匙——2017年诺贝尔化学奖解读[J]. 化学教育（中英文）, 2018, 39(12): 1-10

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