Radiopharmaceuticals is one of the core technologies of positron emission tomography (PET) for diagnostic imaging of various diseases. To make the ¹⁸F (T_1/2=110 min) labeled radiopharmaceuticals available for imaging, a rapid, efficient and automated preparation process is required. With the rapid development of PET technology, there is a strong demand for radiopharmaceutical professionals all over the world. In order to cultivate students' interests in radiochemical labeling technology and popularize the knowledge of radiopharmaceuticals, teachers transformed scientific research on labeling ¹⁸F processes into an unique teaching practice funded by national 973 and 863 programs. Since 2012, a course entitled "chemical comprehensive design experiment for undergraduate students", a simulative experiment of ^18/19F-radiopharmaceutical automated synthesis has been designed and enrolled students majored in chemistry. The teaching experiment was completed by the self-developed auto-synthesizer, Synth8 box, that simulated the synthesis of PET radiopharmaceuticals via electronically controlled valves. The box could be disassembled and assembled by students easily. To avoid handling the radioactive ¹⁸F, none radioactive ¹⁹F processes were carried out by the Synth8 box. Then, the product was analyzed qualitatively and quantitatively by TLC and LC-MS/MS. This course was closely integrated with the practical application of radiopharmaceuticals and transformed the latest scientific research achievements into teaching practice effectively. This experiment expanded the concept of scientific research for undergraduate students, through which it effectively cultivated and stimulated their scientific research literacy and ability. In the past few years, undergraduate students have actively enrolled and enthusiastically contributed to this course. The students always evaluated the course highly.